Non-mitochondrial
Mitochondrial
Transcription defects
Translation defects

Threshold level:
No threshold
Threshold = 1000
Threshold = 5000
Threshold = 10000
Threshold = 20000

Marfan syndromeNeurofibromatosis 1ADOAPKD1Alpers HuttenlocherSengers syndromeCockayne syndromeCystic fibrosisFriedreich ataxiaDGUOK deficiencyLeigh syndromeMIDDLeber optic atrophyMELASMERRFNARPPearson syndromeMNGIECoenzyme Q10 deficiencySANDOPDHP deficiencyTK2 deficiencyMLASA2Sickle cell anemiaHemophilia AAlpha 1 antitrypsin deficiencyvon Hippel LindauEhlers Danlos syndromeFamilial Mediterranean feverPeutz Jeghers syndromePseudoxanthoma elasticumvon Willebrand disease 3IOSCAFamilial hypercholesterolemiaSCID X linkedOpitz GBBB X linkedApert syndromeAlkaptonuriaAchondroplasiaCrouzon syndromePrimary ciliary dyskinesiaG6PDDSDHA deficiencyBarth syndromeHMLMEGDELCMT2A2APDSPseudoachondroplasiaFraser syndromeCDPX1Cutis laxa recessivePEO autosomal dominant 1Kearns-Sayre syndromePDH deficiencySCA28SPG7LSFCLBSLHLD4MC5DN2HLD7SCA17DBA1TCS1NAIC
Figure S2 Diseases associated with transcriptional defects display mitochondrial phenotypes Each dots represents a disease and the connecting lines a shared trait between two diseases. The closer two diseases are the more features they share. Hold the mouse pointer over each dot to see the name of the disease and the connections for that disease. Double-click on a dot to see the clinical data and references describing that disease. By increasing the threshold level only stronger connection will link two diseases. The network is best shown in the Google Chrome browser.