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Prevalence (%) of clinical parameters based on data from 3 references describing 1,405 individuals
Add new symptom/sign to this disease
| Pubmed id number as a reference | Organ system affected | ||
| Number of patients in the reference | Percent affected patients (Between 0 and 1, eg. 0.1 = 10%) | ||
| Please provide your name and contact information as a reference | |||
| Name | Institute | Phone number | Email address |
List of symptoms
| Symptom/sign | Organ system | Percent affected | Pubmed id | Added on(yyyy-mm-dd) | Edit/add reference |
| Limb wasting | nervous | 100 % | 17296839 | 2012-06-10 | |
| Hyperactive reflexes | nervous | 100 % | 19487653 | 2012-08-24 | |
| Muscle weakness | skeletal | 100 % | 19487653 | 2012-08-24 | |
| Motor neuron degeneration | nervous | 100 % | 17296839 | 2020-01-25 | |
| Pyramidal signs | nervous | 99 % | 17296839 | 2012-06-10 | |
| Muscle atrophy | skeletal | 90 % | 19487653 | 2012-08-24 | |
| Bulbar dysfunction | nervous | 88 % | 17296839 | 2012-06-10 | |
| Dysphagia | nervous | 80 % | 19487653 | 2012-08-24 | |
| Dysdiadochokinesia | nervous | 78 % | 19487653 | 2012-08-24 | |
| Weight loss | multi | 70 % | 19487653 | 2012-08-24 | |
| Fasciculations | skeletal | 70 % | 19487653 | 2012-08-24 | |
| Areflexia | nervous | 70 % | 19487653 | 2012-08-24 | |
| Dysarthria | nervous | 60 % | 19487653 | 2012-08-24 | |
| Spasticity | nervous | 22 % | 21702734 | 2012-06-10 | |
| Muscle atrophy | skeletal | 22 % | 21702734 | 2012-06-10 | |
| Dementia | nervous | 8 % | 17296839 | 2012-06-10 |
List of references:
Differentiation between primary lateral sclerosis and amyotrophic lateral sclerosis: examination of symptoms and signs at disease onset and during follow-up.
Maria Carmela Tartaglia, Ann Rowe, Karen Findlater, J B Orange, Gloria Grace, Michael J Strong,
Archives of neurology - Feb 2007
Clinical features that distinguish PLS, upper motor neuron-dominant ALS, and typical ALS.
P H Gordon, B Cheng, I B Katz, H Mitsumoto, L P Rowland,
Neurology - Jun 2009
Uncovering amyotrophic lateral sclerosis phenotypes: clinical features and long-term follow-up of upper motor neuron-dominant ALS.
Mario Sabatelli, Marcella Zollino, Marco Luigetti, Alessandra Del Grande, Serena Lattante, Giuseppe Marangi, Mauro Lo Monaco, Francesca Madia, Emiliana Meleo, Giulia Bisogni, Amelia Conte,
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - Jul 2011