Hutchinson-Gilford progeria
Hutchinson Gilford

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Prevalence (%) of clinical parameters based on data from 3 references describing 42 individuals







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Pubmed id number as a reference Organ system affected
Number of patients in the reference Percent affected patients (Between 0 and 1, eg. 0.1 = 10%)
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List of symptoms



Symptom/sign Organ system Percent affected Pubmed id Added on(yyyy-mm-dd) Edit/add reference
Alopecia integumentary 100 % 18256394 2011-10-19
Failure to thrive multi 100 % 18256394 2011-10-13
Micrognathia skeletal 100 % 18256394 2012-01-19
Short stature multi 100 % 18256394 2012-01-19
Weight loss multi 100 % 18256394 2014-04-14
Arteriosclerosis circulatory 100 % 11485857 2014-06-04
Skin pigmentation changes integumentary 93 % 18256394 2011-10-13
Scleroderma integumentary 80 % 18256394 2011-10-13
Osteoporosis skeletal 73 % 18256394 2011-10-13
Sleeping with eyes open nervous 73 % 18256394 2014-04-14
Circumoral cyanosis circulatory 60 % 18256394 2014-04-14
Stroke nervous 60 % 23179651 2014-06-04
Prominent scalp veins circulatory 53 % 18256394 2014-04-14
Hypertension circulatory 47 % 18256394 2011-10-13
Contracture skeletal 47 % 18256394 2012-01-19
Xerophthalmus integumentary 33 % 18256394 2011-10-13
Cardiac conduction defect circulatory 33 % 18256394 2011-10-13
Long QT circulatory 33 % 18256394 2014-04-14
Kyphosis skeletal 20 % 18256394 2011-10-13



List of references:


Phenotype and course of Hutchinson-Gilford progeria syndrome.
Melissa A Merideth, Leslie B Gordon, Sarah Clauss, Vandana Sachdev, Ann C M Smith, Monique B Perry, Carmen C Brewer, Christopher Zalewski, H Jeffrey Kim, Beth Solomon, Brian P Brooks, Lynn H Gerber, Maria L Turner, Demetrio L Domingo, Thomas C Hart, Jennifer Graf, James C Reynolds, Andrea Gropman, Jack A Yanovski, Marie Gerhard-Herman, Francis S Collins, Elizabeth G Nabel, Richard O Cannon, William A Gahl, Wendy J Introne,



The New England journal of medicine - Feb 2008



Smooth muscle cell depletion and collagen types in progeric arteries.
W E Stehbens, B Delahunt, T Shozawa, E Gilbert-Barness,



Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology -



Imaging characteristics of cerebrovascular arteriopathy and stroke in Hutchinson-Gilford progeria syndrome.
V M Silvera, L B Gordon, D B Orbach, S E Campbell, J T Machan, N J Ullrich,



AJNR. American journal of neuroradiology - May 2013