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Wolfram syndrome

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Prevalence (%) of clinical parameters based on data from 2 references describing 257 individuals







Add new symptom/sign to this disease

Select symptom from list or write it in the box
Pubmed id number as a reference Organ system affected
Number of patients in the reference Percent affected patients (Between 0 and 1, eg. 0.1 = 10%)
Please provide your name and contact information as a reference
Name Institute Phone number Email address


List of symptoms



Symptom/sign Organ system Percent affected Pubmed id Added on(yyyy-mm-dd) Edit/add reference
Diabetes mellitus type 1 endocrine 100 % 20972738 2011-10-19
Optic atrophy nervous 97 % 20972738 2011-10-01
Hearing loss nervous 59 % 20972738 2011-10-01
Diabetes insipidus nervous 53 % 20972738 2011-10-01
Ataxia nervous 33 % 7490992 2011-10-01
Gastrointestinal dysmotility digestive 24 % 7490992 2011-10-01
Areflexia nervous 20 % 7490992 2011-10-01
Myoclonus nervous 20 % 7490992 2011-10-01
Psychiatric symptom nervous 18 % 20972738 2011-10-01
Nystagmus nervous 16 % 7490992 2011-10-01
Apnea nervous 11 % 7490992 2011-10-01
Dysarthria nervous 11 % 7490992 2011-10-01
Cataract nervous 7 % 20972738 2011-10-01



List of references:







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Neurodegeneration and diabetes: UK nationwide study of Wolfram (DIDMOAD) syndrome.
T G Barrett, S E Bundey, A F Macleod,



Lancet (London, England) - Dec 1995