Mito DB

Prevalence (%) of clinical parameters based on data from 2 references describing 257 individuals

Add new symptom/sign to this disease

Select symptom from list or write it in the box		Pubmed id number as a reference	Organ system affected

Number of patients in the reference	Percent affected patients (Between 0 and 1, eg. 0.1 = 10%)

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List of symptoms

Symptom/sign	Organ system	Percent affected	Pubmed id	Added on(yyyy-mm-dd)	Edit/add reference
Diabetes mellitus type 1	endocrine	100 %	20972738	2011-10-19
Optic atrophy	nervous	97 %	20972738	2011-10-01
Hearing loss	nervous	59 %	20972738	2011-10-01
Diabetes insipidus	nervous	53 %	20972738	2011-10-01
Ataxia	nervous	33 %	7490992	2011-10-01
Gastrointestinal dysmotility	digestive	24 %	7490992	2011-10-01
Areflexia	nervous	20 %	7490992	2011-10-01
Myoclonus	nervous	20 %	7490992	2011-10-01
Psychiatric symptom	nervous	18 %	20972738	2011-10-01
Nystagmus	nervous	16 %	7490992	2011-10-01
Apnea	nervous	11 %	7490992	2011-10-01
Dysarthria	nervous	11 %	7490992	2011-10-01
Cataract	nervous	7 %	20972738	2011-10-01

List of references:

WS1 gene mutation analysis of Wolfram syndrome in a Chinese patient and a systematic review of literatures.
Guang Yu, Man-li Yu, Jia-feng Wang, Cong-rong Gao, Zhong-jin Chen,

Endocrine - Oct 2010

Neurodegeneration and diabetes: UK nationwide study of Wolfram (DIDMOAD) syndrome.
T G Barrett, S E Bundey, A F Macleod,

Lancet (London, England) - Dec 1995