Leigh Syndrome |
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Prevalence (%) of clinical parameters based on data from 2 references describing 49 individuals
Add new symptom/sign to this disease
| Pubmed id number as a reference | Organ system affected | ||
| Number of patients in the reference | Percent affected patients (Between 0 and 1, eg. 0.1 = 10%) | ||
| Please provide your name and contact information as a reference | |||
| Name | Institute | Phone number | Email address |
List of symptoms
| Symptom/sign | Organ system | Percent affected | Pubmed id | Added on(yyyy-mm-dd) | Edit/add reference |
| Developmental delay | nervous | 100 % | 8602753 | 2011-10-18 | |
| Developmental delay | nervous | 92 % | 19135620 | 2011-10-05 | |
| Basal ganglia pathology | nervous | 92 % | 19135620 | 2011-10-14 | |
| Lactate accumulation | circulatory | 91 % | 8602753 | 2011-10-05 | |
| Hypotonia | nervous | 86 % | 8602753 | 2011-10-05 | |
| Seizures | nervous | 79 % | 19135620 | 2011-10-05 | |
| Hyperactive reflexes | nervous | 66 % | 8602753 | 2011-10-05 | |
| Muscle weakness | skeletal | 58 % | 8602753 | 2011-10-05 | |
| Apnea | respiratory | 57 % | 19135620 | 2011-10-05 | |
| Spasticity | nervous | 54 % | 8602753 | 2011-10-05 | |
| Failure to thrive | skeletal | 49 % | 8602753 | 2011-10-05 | |
| Nystagmus | nervous | 46 % | 8602753 | 2011-10-05 | |
| Seizures | nervous | 40 % | 8602753 | 2011-10-05 | |
| Ataxia | nervous | 37 % | 8602753 | 2011-10-05 | |
| Ophthalmoplegia | nervous | 36 % | 19135620 | 2011-10-05 | |
| Ophthalmoplegia | nervous | 34 % | 8602753 | 2011-10-05 | |
| Optic atrophy | nervous | 34 % | 8602753 | 2011-10-05 | |
| Vomiting | digestive | 34 % | 8602753 | 2011-10-05 | |
| Chorea | nervous | 29 % | 8602753 | 2011-10-05 | |
| Spasticity | nervous | 21 % | 19135620 | 2011-10-05 | |
| Chorea | nervous | 21 % | 19135620 | 2011-10-05 | |
| Cardiomyopathy | circulatory | 21 % | 19135620 | 2011-10-05 | |
| Dystonia | nervous | 20 % | 8602753 | 2011-10-05 | |
| Ptosis | nervous | 17 % | 8602753 | 2011-10-05 | |
| Retinitis pigmentosa | nervous | 14 % | 19135620 | 2011-10-05 | |
| Vomiting | digestive | 14 % | 19135620 | 2011-10-05 | |
| Mental retardation | nervous | 7 % | 19135620 | 2011-10-05 | |
| Neuropathy | nervous | 6 % | 8602753 | 2011-10-05 |
List of references:
Leigh syndrome: clinical features and biochemical and DNA abnormalities.
S Rahman, R B Blok, H H Dahl, D M Danks, D M Kirby, C W Chow, J Christodoulou, D R Thorburn,
Annals of neurology - Mar 1996
Leigh syndrome: clinical and neuroimaging follow-up.
Hsiu-Fen Lee, Chi-Ren Tsai, Ching-Shiang Chi, Huei-Jane Lee, Clayton Chi-Chang Chen,
Pediatric neurology - Feb 2009