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Prevalence (%) of clinical parameters based on data from 4 references describing 276 individuals
Add new symptom/sign to this disease
| Pubmed id number as a reference | Organ system affected | ||
| Number of patients in the reference | Percent affected patients (Between 0 and 1, eg. 0.1 = 10%) | ||
| Please provide your name and contact information as a reference | |||
| Name | Institute | Phone number | Email address |
List of symptoms
| Symptom/sign | Organ system | Percent affected | Pubmed id | Added on(yyyy-mm-dd) | Edit/add reference |
| Cataract | nervous | 100 % | 16673358 | 2011-10-19 | |
| Cerebral atrophy | nervous | 100 % | 14586596 | 2014-05-13 | |
| Alopecia | integumentary | 100 % | 14586596 | 2014-05-13 | |
| Decreased brain NAA to CR | nervous | 100 % | 14586596 | 2014-05-13 | |
| Weight loss | multi | 100 % | 25059010 | 2014-09-17 | |
| Scleroderma | integumentary | 99 % | 16673358 | 2011-10-13 | |
| Thin limbs | skeletal | 98 % | 16673358 | 2014-09-17 | |
| Graying of hair | integumentary | 96 % | 16673358 | 2011-10-13 | |
| Short stature | multi | 94 % | 16673358 | 2011-10-13 | |
| Osteoporosis | skeletal | 91 % | 16673358 | 2011-10-13 | |
| Hypogonadism | reproductive | 80 % | 16673358 | 2011-10-13 | |
| Diabetes mellitus type 2 | endocrine | 71 % | 16673358 | 2011-10-13 | |
| Diabetes mellitus type 2 | endocrine | 62 % | 22587870 | 2014-05-09 | |
| Hypercholesterolemia | circulatory | 52 % | 22587870 | 2014-05-09 | |
| Cancer | multi | 44 % | 16673358 | 2011-10-13 | |
| Arteriosclerosis | circulatory | 40 % | 16673358 | 2011-10-13 | |
| Hypertension | circulatory | 26 % | 22587870 | 2014-05-09 | |
| Arteriosclerosis | circulatory | 10 % | 22587870 | 2014-05-09 |
List of references:
The spectrum of WRN mutations in Werner syndrome patients.
Shurong Huang, Lin Lee, Nancy B Hanson, Catherine Lenaerts, Holger Hoehn, Martin Poot, Craig D Rubin, Da-Fu Chen, Chih-Chao Yang, Heike Juch, Thomas Dorn, Roland Spiegel, Elif Arioglu Oral, Mohammed Abid, Carla Battisti, Emanuela Lucci-Cordisco, Giovanni Neri, Erin H Steed, Alexa Kidd, William Isley, David Showalter, Janet L Vittone, Alexander Konstantinow, Johannes Ring, Peter Meyer, Sharon L Wenger, Axel von Herbay, Uwe Wollina, Markus Schuelke, Carin R Huizenga, Dru F Leistritz, George M Martin, I Saira Mian, Junko Oshima,
Human mutation - Jun 2006
MR evidence of structural and metabolic changes in brains of patients with Werner's syndrome.
Nicola De Stefano, Maria T Dotti, Carla Battisti, Francesco Sicurelli, Maria L Stromillo, Marzia Mortilla, Antonio Federico,
Journal of neurology - Oct 2003
Werner syndrome: clinical evaluation of two cases and a novel mutation.
A T Mansur, N H Elçioglu, G T Demirci,
Genetic counseling (Geneva, Switzerland) - 2014
Incidence and characteristics of metabolic disorders and vascular complications in individuals with Werner syndrome in Japan.
Emiko Okabe, Minoru Takemoto, Shunichiro Onishi, Takahiro Ishikawa, Ryouichi Ishibashi, Peng He, Kazuki Kobayashi, Masaki Fujimoto, Harukiyo Kawamura, Koutaro Yokote,
Journal of the American Geriatrics Society - May 2012