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Prevalence (%) of clinical parameters based on data from 4 references describing 276 individuals
Add new symptom/sign to this disease
| Pubmed id number as a reference | Organ system affected | ||
| Number of patients in the reference | Percent affected patients (Between 0 and 1, eg. 0.1 = 10%) | ||
| Please provide your name and contact information as a reference | |||
| Name | Institute | Phone number | Email address |
List of symptoms
| Symptom/sign | Organ system | Percent affected | Pubmed id | Added on(yyyy-mm-dd) | Edit/add reference |
| Cataract | nervous | 100 % | 16673358 | 2011-10-19 | |
| Cerebral atrophy | nervous | 100 % | 14586596 | 2014-05-13 | |
| Alopecia | integumentary | 100 % | 14586596 | 2014-05-13 | |
| Decreased brain NAA to CR | nervous | 100 % | 14586596 | 2014-05-13 | |
| Weight loss | multi | 100 % | 25059010 | 2014-09-17 | |
| Scleroderma | integumentary | 99 % | 16673358 | 2011-10-13 | |
| Thin limbs | skeletal | 98 % | 16673358 | 2014-09-17 | |
| Graying of hair | integumentary | 96 % | 16673358 | 2011-10-13 | |
| Short stature | multi | 94 % | 16673358 | 2011-10-13 | |
| Osteoporosis | skeletal | 91 % | 16673358 | 2011-10-13 | |
| Hypogonadism | reproductive | 80 % | 16673358 | 2011-10-13 | |
| Diabetes mellitus type 2 | endocrine | 71 % | 16673358 | 2011-10-13 | |
| Diabetes mellitus type 2 | endocrine | 62 % | 22587870 | 2014-05-09 | |
| Hypercholesterolemia | circulatory | 52 % | 22587870 | 2014-05-09 | |
| Cancer | multi | 44 % | 16673358 | 2011-10-13 | |
| Arteriosclerosis | circulatory | 40 % | 16673358 | 2011-10-13 | |
| Hypertension | circulatory | 26 % | 22587870 | 2014-05-09 | |
| Arteriosclerosis | circulatory | 10 % | 22587870 | 2014-05-09 |
List of references:
The spectrum of WRN mutations in Werner syndrome patients.
Shurong Huang, Lin Lee, Nancy B Hanson, Catherine Lenaerts, Holger Hoehn, Martin Poot, Craig D Rubin, Da-Fu Chen, Chih-Chao Yang, Heike Juch, Thomas Dorn, Roland Spiegel, Elif Arioglu Oral, Mohammed Abid, Carla Battisti, Emanuela Lucci-Cordisco, Giovanni Neri, Erin H Steed, Alexa Kidd, William Isley, David Showalter, Janet L Vittone, Alexander Konstantinow, Johannes Ring, Peter Meyer, Sharon L Wenger, Axel von Herbay, Uwe Wollina, Markus Schuelke, Carin R Huizenga, Dru F Leistritz, George M Martin, I Saira Mian, Junko Oshima,
Human mutation - Jun 2006
MR evidence of structural and metabolic changes in brains of patients with Werner's syndrome.
Nicola De Stefano, Maria T Dotti, Carla Battisti, Francesco Sicurelli, Maria L Stromillo, Marzia Mortilla, Antonio Federico,
Journal of neurology - Oct 2003
Werner syndrome: clinical evaluation of two cases and a novel mutation.
A T Mansur, N H Elçioglu, G T Demirci,
Genetic counseling (Geneva, Switzerland) - 2014
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