North American Indian Childhood Cirrhosis
NAIC

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We were unfortunately unable to download the information for this disease from OMIM.



Prevalence of clinical parameters (%)







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Pubmed id number as a reference Organ system affected
Number of patients in the reference Percent affected patients (Between 0 and 1, eg. 0.1 = 10%)
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List of symptoms



Symptom/sign Organ system Percent affected Pubmed id Added on(yyyy-mm-dd) Edit/add reference
Hepatomegaly circulatory 90 % 11045837 2015-04-01
Portal hypertension circulatory 90 % 11045837 2015-04-01
Increased alkaline phosphatase circulatory 90 % 11045837 2015-04-01
Increased blood transaminase circulatory 90 % 11045837 2015-04-01
Increased blood gammaglutamyltransferase circulatory 90 % 11045837 2015-04-01
Coagulopathy circulatory 90 % 11045837 2015-04-01
Heart murmur circulatory 87 % 11045837 2015-04-01
Telangiectasia circulatory 77 % 11045837 2015-04-01
Otitis media nervous 77 % 11045837 2015-04-01
Bronchial hyperactivity respiratory 77 % 11045837 2015-04-01
Jaundice circulatory 70 % 11045837 2015-04-01
Splenomegaly circulatory 67 % 11045837 2015-04-01
Pruritus integumentary 53 % 11045837 2015-04-01
Epistaxis respiratory 53 % 11045837 2015-04-01
Variceal bleeding digestive 50 % 11045837 2015-04-01
Ascites digestive 27 % 11045837 2015-04-01
Liver failure digestive 20 % 11045837 2015-04-01
Short stature skeletal 13 % 11045837 2015-04-01
Cardiac structural defects circulatory 7 % 11045837 2015-04-01
Spontaneous bacterial peritonitis digestive 6 % 11045837 2015-04-01
Hematemesis digestive 3 % 11045837 2015-04-01



List of references:


North American Indian cirrhosis in children: a review of 30 cases.
E Drouin, P Russo, B Tuchweber, G Mitchell, A Rasquin-Weber,

North American Indian childhood cirrhosis (NAIC) is a distinct, rapidly evolving form of familial cholestasis found in aboriginal children from northwestern Quebec. This is a retrospective review of the 30 patients treated in Quebec since the discovery of NAIC in 1970.

Journal of pediatric gastroenterology and nutrition - Oct 2000