Progressive external ophthalmoplegia, autosomal dominant, 3
PEO autosomal dominant 3

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Prevalence (%) of clinical parameters based on data from 2 references describing 38 individuals







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 Pubmed id number as a reference Organ system affected
Number of patients in the reference Percent affected patients (Between 0 and 1, eg. 0.1 = 10%)
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List of symptoms



Symptom/sign Organ system Percent affected Pubmed id Added on(yyyy-mm-dd) Edit/add reference
Ophthalmoplegia nervous 100 % 17620490 2011-10-11
Ptosis nervous 97 % 20479361 2011-10-11
Ophthalmoplegia nervous 94 % 20479361 2011-10-19
Tremor nervous 60 % 17620490 2011-10-10
Parkinsonism nervous 60 % 17620490 2011-10-10
Fatigue skeletal 52 % 20479361 2011-10-05
Cox-negative muscle fibers skeletal 40 % 17620490 2011-10-05
Muscle weakness skeletal 33 % 20479361 2011-10-11
Cardiomyopathy circulatory 24 % 20479361 2011-10-11
Psychiatric symptom nervous 20 % 17620490 2011-10-10
Neuropathy nervous 20 % 17620490 2011-10-10
Dysphagia nervous 12 % 20479361 2011-10-11
Headache nervous 9 % 20479361 2011-10-11
Hearing loss nervous 9 % 20479361 2011-10-11
Cataract nervous 9 % 20479361 2011-10-11



List of references:


Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle.
Robert H Baloh, Ezequiel Salavaggione, Jeffrey Milbrandt, Alan Pestronk,



Archives of neurology - Jul 2007



The clinical, histochemical, and molecular spectrum of PEO1 (Twinkle)-linked adPEO.
C Fratter, G S Gorman, J D Stewart, M Buddles, C Smith, J Evans, A Seller, J Poulton, M Roberts, M G Hanna, S Rahman, S E Omer, T Klopstock, B Schoser, C Kornblum, B Czermin, B Lecky, E L Blakely, K Craig, P F Chinnery, D M Turnbull, R Horvath, R W Taylor,



Neurology - May 2010